DAXX and infection: Interestingly, abolishing pp71′s ability to interact with hDaxx blocks pp71′s localization at ND10 and inhibits pp71′s ability to transactivate the major immediate early promoter (MIEP) of HCMV [121,122,124], indicating that the association of pp71 with hDaxx in ND10 is critical for its function as a facilitator of IE gene expression at the very start of a lytic infection.