Interestingly, novel findings from Sivachandran et al. demonstrate that EBV latent infection in NPC cells is also associated with a modification of ND10 integrity and that EBNA1 is responsible for this effect by decreasing PML protein levels in a proteasome-dependent manner as well as through interaction with the cellular ubiquitin-specific protease USP7/HAUSP [151]. This evidence concerns the gene USP7 and nasopharyngeal carcinoma.