MYC and neoplasm: Several observations have initially let hypothesize that, although c-myc triggering cellular growth may play a role in the premalignant steps during the process of malignant transformation (as reflected by its high mRNA steady state level in peritumor liver), it might not play a significant role in sustaining the growth of the tumor cells (as reflected by its lower mRNA steady state level in the corresponding tumor tissue) [68–69].