Finally, the generation of pro-inflammatory cytokines and growth factors produced by tumour infiltrating macrophages, lymphocytes and other cell types in the tumour microenvironment provokes activation of NF-κB, protects against pro-apoptotic host immune defence mechanisms, influences cell differentiation and exert proangiogenic effects which stimulate the growth of cancer cells, tumour invasiveness and metastasis [98]. This evidence concerns the gene NFKB1 and neoplasm.