However, this picture may be even more complex, as two profiles of IL-7Rα expression have been observed in chronic HCV patients: most patients have exhausted HCV-specific CD8+ T cells, with low IL-7Rα expression, low proliferative and IFN-γ secretion potential, but some patients have HCV-specific T cells that express high levels of IL-7Rα expression and maintain an efficient proliferative and IFN-γ secretion potential, similar to HCV-specific T cells from patients who resolved their infection [96]. The gene discussed is CD8A; the disease is infection.