In this paper we focused on the effects of THSG on PPAR-γ and the NF-κB-induced inflammatory mediators TNF-α, IL-6, COX-2 in an mouse experimental model of colitis induced by acetic acid, with the aim of revealing the underlying mechanisms of the beneficial effects of THSG on colitis and provide evidence that THSG may be a promising new candidate or lead compound for the treatment of IBD. The gene discussed is TNF; the disease is inflammatory bowel disease.