Among the steps of the complex inflammatory response in the IBD process, activation of NF-κB leads to NF-κB dimers (p65 and p50) that translocate to the nucleus to promote transcription of the pro-inflammatory mediators TNF-α, IL-6 and COX-2, which then result in a series of inflammatory cascade responses [3,4]. The gene discussed is NFKB1; the disease is inflammatory bowel disease.