Previous studies have demonstrated that the induction of ketosis in mild to moderate AD patients improves scores in the Alzheimer's Disease Assessment Scale -Cognitive subscale (ADAS-Cog) relative to placebo among non-carriers of the APOE4 allele using both acute [14] and chronic [15] dosing regimens. The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.