In particular, low OPN levels were significantly associated with a favorable prognosis in patients with advanced non-small cell lung cancer [15], laryngeal and hypopharyngeal carcinomas [16], hepatocellular carcinoma [17], colorectal cancer [18], idiopathic pulmonary hypertension [19], upper urinary tract urothelial carcinoma [20], acute myeloid leukemia [21], oral squamous cell carcinoma [22], and endometrial cancer [23]. This evidence concerns the gene SPP1 and hepatocellular carcinoma.