ADRB3 and obesity due to melanocortin 4 receptor deficiency: For AH and type 2 DM after including only sex and polymorphism of the ADRB3 as independent variables the Arg64 allele increased the odds ratio for AH (OR 1.92; 95% CI 1.1-3.6) and for type 2 DM (OR 2.85; 95% CI 1.34-6.06), but after adjusting for obesity the role of Arg64 allele lost its statistical significance in both models.