ADRB3 and obesity due to melanocortin 4 receptor deficiency: In a forward stepwise logistic regression model that included obesity as a dependent variable and the polymorphism of the ADRB3 (with Trp64 allele as reference) and sex as independent variables, only the presence of the Arg64 allele reached statistical significance (OR 3.16; 95% CI 1.79-5.56).