The gut fluid uptake (GFU) in the TPO (0.195 ± 0.004 ml/g sac/30 minutes) was also significantly (P <  .001) lower than control (0.414 ± 0.009 ml/g sac/30 minutes) or FPO (0.360 ± 0.005 ml/g sac/30 minutes), no statistically significant difference was recorded in the GFU between FPO and control. The gene discussed is TPO; the disease is otopalatodigital syndrome type 2.