A recent study has demonstrated the uptake of IL-10-secreting Lc. lactis by the paracellular route in inflamed mucosal tissue in mouse models of chronic colitis, suggesting that IL-10 production by these LAB residing inside the mucosa in the vicinity of responsive cells can improve the local action of IL-10 in inflamed tissue and the efficiency of the treatment [88]. The gene discussed is IL10; the disease is Chronic colitis.