Frulloni et al. reported that 94% of AIP patients, but only 5% of pancreatic cancer patients, exhibit IgG antibodies to a plasminogen-binding protein (PBP) that is homologous to the human protein ubiquitin-protein ligase E3 component n-recognin 2 (UBR2), which is expressed in pancreatic acinar cells and is also homologous to the PBP of H. pylori [67]. This evidence concerns the gene UBR2 and pancreatic neoplasm.