Calcitriol can lower the IL-8 levels in two immortalized human prostate epithelial cell lines (HPr-1 and RWPE-1) and three prostate cancer cell lines (i.e., LNCaP, PC-3, and DU145) [87], by reducing NFκB p65 nuclear translocation and gene transcription of IL-8. The gene discussed is CXCL8; the disease is Familial prostate cancer.