For HPV18, the statistically significant difference were seen for HSIL when the tissue source was fixed biopsies (compared to exfoliated cells) and when MY and GP performed together were used compared to Hybridization techniques and for cancer when the tissue source were Polymerase Chain Reaction SPF, GP5/6, E6, E7 and others compared to Hybridization techniques. This evidence concerns the gene GP5 and cancer.