Also consistent with previous reports [3,7-9], there was no correlation between cell surface NIS protein and breast tumor subtype (p = 0.50), hormone receptor status (ER, p = 0.17; PR, p = 0.58; Her-2/neu, p = 0.97), p53 status (p = 0.71), tumor grade (p = 0.57), or the presence of lymph node metastases (p = 0.59) (Table 2). Here, ESR1 is linked to neoplasm.