Elevated levels of various inflammatory mediators such as tumor necrosis factor alpha (TNFα), interleukin (IL)-1β, IL-2, IL-6, interferon γ, inducible nitric oxide synthase (iNOS) and cyxlooxygenase-2 (COX-2), together with the presence of activated microglia and astrocytes, have all been observed in the brain of PD patients [3-15]. The gene discussed is NOS2; the disease is Parkinson disease.