Because apoptosis is likely to play an important role in degenerating processes of the SNpc in the subacute MPTP model of PD used here, cellular-debris-derived damage associated molecular pattern molecules (DAMPs), as the result of cell death, could have generated a secondary inflammatory response driven by the MyD88-dependent pathway, creating additional dopaminergic death as observed, for example, in stroke models [80]. Here, MYD88 is linked to Stroke.