We have assessed the involvement of 7 single nucleotide polymorphisms (SNPs) (Arg 677Trp, Arg753Gln, rs1898830, rs11938228, rs3804099, rs3804100, and rs7656411) as well as a short tandem GT repeat polymorphism in intron 2 of the TLR2 gene in the risk of developing late-onset AD (LOAD) [8,9], and found an association of GT repeat polymorphism with an increased risk for LOAD in our previous studies. This evidence concerns the gene TLR2 and Alzheimer disease.