Disruption of PARP-1 caused a high incidence (49%) of aggressive brain tumours in p53 null mice, with typical features of human cerebellar medulloblastomas, thus implicating PARP-1 in tumour suppression (Tong et al, 2003; Rouleau et al, 2010). The gene discussed is PARP1; the disease is Cerebellar medulloblastoma.