PIMREG and neoplasm: In a multivariate model, adjusted for disease stage, LVI status and tumour site, the interaction between CatS expression and treatment status was significant for both RFS (HR 0.46; 95% CI, 0.24–0.90; P=0.02) and OS (HR 0.49; 95% CI, 0.50–0.96; P=0.04; Table 4).