Our finding that sICAM-1 was associated with increased odds for prediabetes and diabetes is consistent with the association reported by the Women's Health Initiative Observational Study (OR for the highest verses lowest quartile of ICAM-1 values: 2.34, 95% CI 1.75, 3.13) but the odds were higher in the Nurse's Health Study (OR for the highest verses lowest quintile of ICAM-1 values: 3.56, 95% CI 2.28, 5.58), possibly due to analysis by quintiles rather than tertiles of biomarker concentration [18,19]. This evidence concerns the gene ICAM1 and prediabetes syndrome.