When we analyzed the subgroups with all variables included at the time of diagnosis according to the BCLC tumor stage, the serum PIKVA-II (P < 0.001) and serum AFP (P = 0.023) in stage A, and serum PIVKA-II (P = 0.047) in stage C were risk factors for extrahepatic metastases in univariate analysis. The gene discussed is AFP; the disease is neoplasm.