When we analyzed the subgroups with all variables included at the time of diagnosis according to the AJCC tumor stage, the serum PIKVA-II (P < 0.001) and platelet count (P = 0.022) in stage I, serum AFP (P = 0.018) and PIVKA-II (P = 0.008) in stage II, and serum PIVKA-II (P = 0.023) and platelet count (P = 0.031) in stage III were risk factors for extrahepatic metastases in univariate analysis. This evidence concerns the gene AFP and neoplasm.