AFP and Portal vein thrombosis: The patients with a PIVKA-II ≥ 300 mAU/mL had a 2.7-fold (95% confidence interval [CI], 1.535-4.812, P = 0.001) and a 3.7-fold (95% confidence interval [CI], 2.073-6.560, P < 0.001) in AJCC and BCLC hazard ratios of extrahepatic metastases, respectively, when the those with AFP ≥ 400 and PIVKA-II ≥ 300 in Cox regression analysis after adjustment for portal vein thrombosis, platelet count, and stage were applied.