It has been shown to block tumour cell proliferation and angiogenesis by inhibiting serine⁄ threonine kinases [c-RAF, and mutant and wildtype B-RAF (v-raf murine sarcoma viral oncogene homolog B1)] as well as the receptor tyrosine kinases VEGFR2, VEGFR3, PDGFR, FLT3, RET and c-KIT. The gene discussed is BRAF; the disease is neoplasm.