Tetanus conditioning revealed a marked difference in the ability of transgenic HD mice to support LTP, with strengthening of PS significantly low in R6/2 and R6/2:pGFAP-BDNF mice, whereas wt and pGFAP-BDNF mice had a significant PS response (Figure 8C, p < 0.001). Here, BDNF is linked to Huntington disease.