ORMDL3 as a candidate gene for asthma susceptibility has been replicated in 8 white populations (Scottish [7], French-Canadian [8,9], French [8], German and British ancestry [3], North Americans of European ancestry [10], Mexicans in Mexico City [11] and Australia [12]), 3 ethnically diverse populations (Mexicans, Puerto Ricans and African Americans) [13], and 2 Asian populations (Japanese [14] and Chinese [Hong Kong][15]). This evidence concerns the gene ORMDL3 and asthma.