A similar observation stands true regarding glutaredoxin 5 (an assembly factor for cellular ISC) [27] (Figure 1), as a mutation in the exon 1 of the GLRX5 gene, putatively leading to a deleterious splicing defect, results in sideroblastic anaemia without ataxia and no overlap with the FA phenotype [28]. This evidence concerns the gene GLRX5 and Friedreich ataxia.