AICDA and cancer: Despite we did not find any specific expression pattern of AID-Δex4 in nasal polyps, the established algorithm can be further applied to test the hypothesis whether the ratio [AID-FL∶ AID-Δex4] might have a prognostic value for certain diseased conditions including chronic inflammation, autoimmunity, and cancer and/or might correlate with an increased potential for AID off-target effects.