In fact, diabetes is considered an inflammatory disease that is characterized by increases in oxidative stress (e.g., the oxidation of glucose) and advanced glycation end-products (AGE) [23], [28], which induce the up-regulation of many inflammatory cytokines, such as MCP-1, TNF-α, IL-1, and IL-6 [29], [30]. This evidence concerns the gene IL1B and diabetes mellitus.