We and Others previously demonstrated that cell adhesion on collagen IV is RGD-independent [27], [28], [29]; as preliminary data necessary for the following experiments, we investigated the adhesion effects of RGDS onto SK-MEL-110 melanoma cells; Figure 1 shows that both RGDS and RAM inhibit adhesion of SK-MEL-110 seeded onto plastic, vitronectin, fibronectin, laminin and von Willebrand Factor in a dose-dependent way, with comparable potency and IC50 values, while they both lack relevant anti adhesion action onto collagen IV-seeded cells. This evidence concerns the gene FN1 and melanoma.