Importantly, when a low dose of RB200 was combined with a suboptimal dose of the TNFα inhibitor etanercept (also given on days 1, 4 and 7 of arthritis), a marked beneficial response was observed, with the combination of 0.5 mg/kg RB200 and 1 mg/kg etanercept having a marked effect on both measures of disease activity in CIA (Figure 3). This evidence concerns the gene TNF and arthritic joint disease.