This kind of malformation has been treated to date with surgical therapy, such as nephrectomy, which is still considered as the first-choice treatment by some authors for patients who present with alterations in the cardiovascular system, such as renin-mediated hypertension caused by fistula-related relative ischemia or high-output cardiac failure caused by an increase in venous return [17]. The gene discussed is REN; the disease is hypertensive disorder.