ERBB2 and ovarian cancer: RAD51C-R214C is an exon 4 mutation and was found in an African-American proband who was diagnosed with stage IIA, ER/PR positive, Her2/Neu positive, infiltrating ductal carcinoma of the breast at age 42, and who had a family history of both breast and ovarian cancers on her mother's side of the family (Figure 3A).