For example, in vascular tissues AMPK activation appears to be a shared molecular target [14] for the beneficial effects of several interventions including physical exercise [15], statins, thiazolidinediones (TZDs) [16], leptin [17], [18], adiponectin [19], [20], [21], and rosiglitazone in diabetes [22], [23], [24]. The gene discussed is PRKAA1; the disease is diabetes mellitus.