MAPT and Alzheimer disease: The former recognizes PHF-tau phosphorylated at Ser212 and Thr214, two amino acids selectively phosphorylated in AD brains [45]; The latter recognizes PHF-tau phosphorylated at Thr231 and Ser235, two amino acids that are physiologically phosphorylated in immature and adult brains, but are strongly hyperphosphorylated in AD brains [46].