CILK1 and endocrine-cerebro-osteodysplasia syndrome: We used two different methods, namely cDNA microarrays and the mRNA deep sequencing platform, to profile transcriptomes of fibroblasts from patients with ECO syndrome due to the homozygous R272Q mutation in ICK. We identified a hyperproliferative phenotype for cultured ECO cells and showed differential expression of genes involved in cell growth and proliferation.