There are 19 RA-associated proteins mapped in the PPI network (HLA-DRB1, STAT4, FCRL3, TRAF1, CCL21, CD40, CDK6, PTPN22, SLC22A4, IRF5, CTLA4, TNFAIP3, CCR6, REL, SPRED2, BLK, FAM107A, and IL2RA). The gene discussed is SPRED2; the disease is rheumatoid arthritis.