With respect to transmural progression, early stage tumors (T1 and T2) presented TKTL1 expression values between 1.8 and 45.5 a.u. (mean 16.5±12.6), while expression of the enzyme in more advanced primary tumor (T3 and T4) ranged from 4.0 to 50.0 a.u. (mean 25.5±11.8). This evidence concerns the gene TKTL1 and neoplasm.