Recently, Lowe and colleagues, identified a non-redundant role for RB, but not p107 and p130, in promoting senescence by specifically repressing E2F-target genes involved in DNA replication [17], providing a rationale for why RB, but not its family members p107 and p130, is disabled in many, if not all, tumor cells [44]. The gene discussed is RB1; the disease is neoplasm.