FGF2 and neoplasm: It has been proposed that a wide variety of cytokines secreted by tumor cells such as vascular endothelial growth factor (VEGF) [3], basic fibroblast growth factor (bFGF), platelet-derived growth factor (PDGF) [4], erythropoietin [5], and insulin-like growth factor (IGF) [6] may stimulate angiogenesis.