Induction of VEGF production by CoCl2 has been shown before in human fibroblasts [38], lung cancer cell line [39], retina epithelium [40], glioma cell lines [41], prostate cancer cell lines [42] and in astrocytes [43], however there was no attempt to investigate the potential production of PGE2 or its autocrine effects. This evidence concerns the gene VEGFA and prostate cancer.