To verify whether inhibition of VEGF production by Caco-2 stimulated with hypertonic stress was a consequence of PGE2 action and not a consequence of the nonespecific action of pharmacological drugs used in the experiments, we performed the same experiment in HCT116, a colon cancer cell line that does not express COX-2 and produces no detectable levels of PGE2 under hypertonic stress. Here, VEGFA is linked to malignant colon neoplasm.