Among the mRNAs up-regulated in the metastatic line, some have been reported to have a role in tissue invasion and/or metastasis of a variety of cancer cells, including mRNA expressed by FSCN1[42], VEGFA[43]FGFR1[44], ADAMTS1[45], CCL2[46] and VIM[47] genes. This evidence concerns the gene VEGFA and cancer.