Despite a paucity of other genes within close proximity to rs17691914, we are intrigued that this SNP achieved genome-wide significance in the initial GWAS and that the 3p22.3 is also tagged by a SNP (rs12638540) within an intron of the CKLF-like MARVEL transmembrane domain containing 7 gene (CMTM7) that is reported to be significantly associated with heart failure mortality (Hazard Ratio = 1.53; P = 3.21×10−7) in a GWAS meta-analysis of 2,526 ambulatory patients [13]. This evidence concerns the gene CMTM7 and heart failure.