SCN2B and heart failure: These include genes encoding interleukin-10 receptor A (IL10RA), which may participate in the oxidative-stress responses that promote cardiac remodeling and heart failure [17], and 2 sodium channel subunits (SCN4B and SCN2B) that are expressed in cardiac myocytes and are mutated in long-QT syndrome and atrial fibrillation, respectively [18], [19].