Thus, the specificity, the potency, and the sustainability of the ‘knock-out’ punch of nimesulide on PEL cells could be attributed to additive anti-viral effects by the blockade of KSHV latency genes LANA-1/vFLIP, anti-inflammatory/anti-survival properties by the down-regulation of VEGF-C, Akt1/2, and GSK-3β, anti-PEL specific properties by down-regulating syndecan-1, VDR, and aquaporin-3 as well as anti-cancer properties by the activation of G1 arrest and apoptosis (Fig. 11). The gene discussed is AQP3; the disease is cancer.