Although the direction and magnitude of association for 8 SNPs (at the UMOD, GCKR, PIP5K1B, PRKAG2, STC1, VEGFA, SHROOM3, and ALMS1/NAT8 loci) were consistent with our previous findings for eGFR and prevalent CKD [16], [17], only two SNPs showed nominally significant associations with ESRD (Table 2): rs1260326 in GCKR (OR =  0.93; p-value = 0.03) and rs12917707 in UMOD (OR =  0.92; p-value = 0.04). This evidence concerns the gene NAT8 and chronic kidney disease.