Four aspects may have contributed to this favourable result: (i) the authors utilised both the positive impact of the GLA therapy on the metabolic control as well as on the frequency of hypoglycaemia; (ii) it is the only modelling study in this review that accounted for the costs of needles for insulin injection and disposables for blood glucose self-monitoring; (iii) utility decrements following the concept of fear of hypoglycaemia were applied; (iv) furthermore Brändle et al. [25] as well as McEwan et al. [23] used relatively high utility decrements compared to Cameron und Bennett [21]. This evidence concerns the gene INS and Hypoglycemia.