In multivariate Cox regression analysis, including lymph node status, age, tumor size, and histological grade, only the combined B-Cell/IL8-metagene score showed strong independent prognostic value in both the discovery cohort (HR 0.38, 95% CI 0.22 to 0.67, P = 0.001) and in the second, larger validation cohort-C, (HR 0.21, 95% CI 0.07 to 0.62, P = 0.005). Here, CXCL8 is linked to neoplasm.