LGR5 and telomere syndrome: We performed a Kaplan-Meier analysis, which detected that STS patients with a lower intratumoral expression of wild type LGR5/GPR49 mRNA died an average of 30 months earlier (P = 0.056), with lower intratumoral GPR49Δ5 mRNA expression died an average of 40 months earlier (P = 0.004) than patients who had higher intratumoral expression of wild type LGR5/GPR49 mRNA and GPR49Δ5 mRNA, respectively (Table 1).