LGR5 and telomere syndrome: Multivariate Cox's regression hazard analysis revealed an increased risk (RR = 1.8, P = 0.12, Table 1) of tumor-related death for patients with a low wild type LGR5/GPR49 mRNA level and a 2.6-fold (P = 0.026) increased risk for STS patients with a low level of GPR49Δ5 mRNA in their tumors, respectively (Figure 1).