In a rat model of I/R injury, Hua and colleagues reported that adenoviral expression of dn-MyD88 three days prior to the onset of myocardial ischemia led to reduced infarct sizes and attenuated NF-κB activity, consistent with the notion that MyD88 signaling may contribute to ischemic myocardial injury by attenuating inflammatory response that is dependent on NF-κB signaling. This evidence concerns the gene NFKB1 and myocardial ischemia.