Univariate analysis between skin AF-EEMS and traditional risk factors and disease-related factors for CVD in SSc patients resulted in a positive correlation between skin AF-EEMS and CRP (r = 0.44, P = 0.004), as well as MSS (r = 0.45, P = 0.006) and use of ACE inhibitors or ATII receptor blockers (r = 0.33, P = 0.027). The gene discussed is CRP; the disease is systemic sclerosis.