Further investigation of the pmt mutants will be helpful for understanding their molecular mechanism, which will not only increase our understanding of the function of O-mannosylation in A. fumigatus, but also may deepen our understanding of the molecular basis of the human Walker-Warburg Syndrome (WWS) which features mutations in POMT1, a homologue of A. fumigatus Pmt4p, and results in a failure of polarized growth during neuronal migration [13]. The gene discussed is POMT1; the disease is muscular dystrophy-dystroglycanopathy, type A.