G6PD and G6PD deficiency: Although there have been several studies aiming at the mathematical representation and simulation of the metabolism in patients with G6PD deficiency [20, 30–32], no studies have sought to interpret the pathways for drug-induced ROS production or determine the kinetic properties that make G6PD-deficient RBCs suffer exceptionally from critical redox imbalance after acute exposure to an oxidative agent.