Several tumor-suppressor genes regulate angiogenesis inhibition, including p53, Rb, vHL, phosphatase and tensin homolog (PTEN), and trk B [84] Wild-type p53 controls expression of the angiogenesis inhibitor thrombospondin and decreases tumor neovascularization; mutant p53 leads to the opposite effect [73]. The gene discussed is RB1; the disease is neoplasm.