PIGA and paroxysmal nocturnal hemoglobinuria: Nevertheless, Pig-a mutations have been confirmed in GPI-anchor deficient rat splenic T-cells [Miura et al.,2008; Miura et al.,2011], and in patients with the GPI-anchor deficiency disorder, paroxysmal nocturnal hemoglobinurea (PNH) [Nishimura et al.,1999].